KMID : 1134120110140030185
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Journal of Breast Cancer 2011 Volume.14 No. 3 p.185 ~ p.190
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G-protein Coupled Estrogen Receptor 1 Expression in Primary Breast Cancers and Its Correlation with Clinicopathological Variables
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Luo Hao-Jun
Luo Ping Yang Guang-Lun Peng Qiong-Le Liu Man-Ran Tu Gang
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Abstract
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Purpose: G-protein coupled estrogen receptor 1 (GPER) probably play important roles in the progression of breast cancer including endocrine therapeutic resistance. We evaluated GPER in primary breast cancers.
Methods: Immunohistochemistry was used to detect GPER in paraffin-embedded tissues of primary breast cancers from 423 patients and GPER expression was correlated with clinicopathological factors.
Results: GPER was expressed in 63.8% of specimens, coexpressed with estrogen receptor alpha (ER¥á) in 36.6% of tumors and was positive in 62.5% of the ER¥á-negative tumors. The expression of GPER had no relationship with the status of ER¥á, progesterone receptor and HER2. Although the expression of GPER was significantly inversely related with nodal status (p=0.045), no correlation between GPER expression and other clinicopathological variables (age, menstruation status, tumor size, stage, histologic grade, Nottingham Prognostic Index or pathological type) was found.
Conclusion: GPER and ER¥á exhibited independent expression pattern of distribution in primary breast cancers. A long-term follow-up and a more definite molecular phenotype for ER are necessary in confirming studies.
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KEYWORD
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Breast neoplasms, G-protein coupled estrogen receptor 1, Immunohistochemistry
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